Recombinant Human IL-17A
- 货号：EPT053
- 价格：￥600.00 元
- 点击：667
产品介绍
基本信息
| 规格 | 10ug |
|---|---|
| 表达宿主 | E.coli |
| 标签 | NA |
物理性质
| 分子量 | 15.26 KDa |
|---|---|
| 表观分子量 | 16 KDa, reducing conditions |
| 形态 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| 纯度 | Greater than 95% as determined by reducing SDS-PAGE. |
活性与内毒素
| 内毒素水平 | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
|---|---|
| 活性 | Immobilized Human IL-17A(Cat#C021) at 2μg/ml (100 μl/well) can bind Anti-Human IL-17A mAb(Cat#NC012).The ED50 of Anti-Human IL-17A mAb(Cat#NC012) is 0.185 ug/ml. |
储存与运输
| 溶解方法 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
|---|---|
| 储存方法 | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
详细说明
| 背景说明 | Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation. |
|---|
相关产品:
| 产品名称 | 点击数 |
|---|---|
| 犬C反应蛋白 | 3443 |
| 猫冠状病毒N、S真核蛋白 | 3396 |
| 犬腺病毒纯化灭活抗原 | 3503 |
| 犬瘟热纯化灭活抗原 | 3463 |
| 犬细小纯化灭活抗原 | 3394 |
| 猫白血p27真核蛋白 | 3076 |
| 猫杯状病毒FCA-S重组蛋白 | 4415 |
| 猫疱疹病毒FHV-GD真核蛋白 | 4148 |
| 禽传染性支气管炎N蛋白 | 4368 |
| 禽法氏囊VP2真核蛋白 | 4050 |
| 新城疫F 、HN真核蛋白 | 4271 |
| 禽白血病P27真核蛋白 | 4089 |
| 禽支原体真核蛋白 | 4109 |
| 禽流感H5、H9重组蛋白 | 4446 |
| 猴痘病毒A29真核蛋白 | 3901 |
| 人呼吸道合胞病毒 | 4405 |
| 甲型、乙型流感病毒A.B | 4344 |
| 人新型冠状病毒S/N真核蛋白 | 4513 |
| 登革热灭活抗原 | 4142 |
| 风疹抗原 | 4043 |