美法仑抗体（Anti-Melphalan antibody）
- 货号：RB9A37060381
- 价格：面议
- 点击：1853
产品介绍
产品描述
| 中文名称 | Anti-Melphalan抗体 |
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| 英文名称 | Anti-Melphalan antibody |
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| 靶点符号 | Melphalan |
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| 产品类型 | 一抗 |
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关键信息
| 宿主种属 | Mouse |
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| 克隆 | Monoclonal |
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| 亚型 | IgG2b |
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| 不含载体蛋白 | No |
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| 应用 | ELISA |
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| 特异性 | This antibody recognises the ring-opened structure that forms when DNA is alkylated by the anti-cancer drug melphalan and is then exposed to alkali. The alkali causes guanine bases alkylated at the N7 position to undergo a so-called ring-opening reaction and this antibody appears to recognise this structure, although recognition may be influenced by the neighbouring DNA sequence. The products of the ring-opening reaction are more resistant to depurination reactions than the original guanine adducts. This antibody was developed to improve detection of melphalan-DNA adducts through its ability to recognise the stabilised adduct. The clone did not bind to alkali-treated control DNA or to DNA that had been alkylated with melphalan but not exposed to alkali. This antibody can be used for quantification of melphalan adducts in purified DNA by ELISA and for immunofluorescent detection of melphalan-DNA adducts in single cells. |
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储存与纯化
| 形式 | Liquid |
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| 纯化工艺 | Affinity purification Protein A/G |
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| 存储溶液 | Preservative: 0.02% Sodium azide Constituents: PBS |
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| 储存信息 | Avoid freeze / thaw cycle |
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