Research Grade Batiraxcept|Batiraxcept（研究用级别）(靶标：Batiraxcept融合蛋白)
- 货号：RB9THC347036
- 价格：面议
- 点击：312
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 抗体亚型 | Fusion - [AXL (AXL receptor tyrosine kinase, ARK, |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 浓度 | 1mg/ml |
| 内毒素水平 | Please contact the lab for this information. |
| 应用 | ELISA, Functional assay, Research in vivo |
| 种属反应性 | Human |
| 靶标 | AXLLG, Growth arrest-specific protein 6, AXL receptor tyrosine kinase ligand, GAS6, GAS-6 |
| 储存缓冲液 | 0.01M PBS, pH 7.4. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 表达系统 | Mammalian Cells |
| 登录号 | Q14393 |
| 背景信息 | Batiraxcept (AVB-S6-500) is a highly potent and specific AXL inhibitor, a recombinant fusion protein dimer containing the extracellular domain of human AXLM and human immunoglobulin G1 heavy chain (Fc). Batiraxcept binds to GAS6 and inhibits the interaction of GAS6 with AXL, thereby substantially reducing AXL signaled invasion and migration of highly metastatic cells in vitro and inhibiting metastatic disease in nonclinical models of aggressive human cancers. Batiraxcept is available for studies in advanced or metastatic clear cell renal cell carcinoma (ccRCC) and platinum sensitive recurrent ovarian cancer. • AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications., PMID:31684958 • The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion., PMID:34244439 • GAS6 attenuates sepsis-induced cardiac dysfunction through NLRP3 inflammasome-dependent mechanism., PMID:37979891 • Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily., PMID:17064312 • Growth arrest-specific protein-6/AXL signaling induces preeclampsia in rats†., PMID:31347670 • Growth arrest-specific protein 6 (Gas6) attenuates inflammatory injury and apoptosis in iodine-induced NOD.H-2h4 mice., PMID:31129420 • A review on the role of GAS6 and GAS6-AS1 in the carcinogenesis., PMID:34481213 • Growth arrest-specific protein 6 (Gas6) as a noninvasive biomarker for early detection of diabetic nephropathy., PMID:28513288 • Gas6-Axl signal promotes indoor VOCs exposure-induced pulmonary fibrosis via pulmonary microvascular endothelial cells-fibroblasts cross-talk., PMID:38824778 • Growth Arrest-Specific 6 in Chromophobe Renal Cell Carcinoma., PMID:35760058 |
| 别名 | AVB-500, AVB-S6-500, Aravive-S6, MYD1Fc, Ruga-S6, 2268717-61-7 |
| 备注 | For research use only. Not suitable for clinical or therapeutic use. |
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