Research Grade Rilonacept|Rilonacept（研究用级别）(靶标：Rilonacept融合蛋白)
- 货号：RB9THF943036
- 价格：面议
- 点击：200
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Human |
| 抗体亚型 | Fusion - [IL1RAP (interleukin-1 receptor accessory |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 浓度 | 1.72mg/ml |
| 内毒素水平 | Please contact the lab for this information. |
| 应用 | ELISA, Functional assay, Research in vivo |
| 种属反应性 | Human |
| 靶标 | Interleukin-1 beta, IL1B, Catabolin, IL1F2, IL-1 beta |
| 储存缓冲液 | 0.01M PBS, pH 7.4. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 表达系统 | Mammalian Cells |
| 登录号 | P01584 |
| 背景信息 | Rilonacept (Arcalyst), a dimeric fusion protein, is a interleukin 1 inhibitor. Rilonacept consists of the ligand-binding domains of the extracellular portions of the IL-1R components linked to the Fc portion of human IgG1. Rilonacept can be used for the research of cryopyrin-associated periodic syndromes. • Understanding the mechanism of IL-1β secretion., PMID:22019906 • NLRP3 inflammasome mediates M1 macrophage polarization and IL-1β production in inflammatory root resorption., PMID:31976565 • The role of IL-1β and TNF-α in intervertebral disc degeneration., PMID:32853910 • Human Monocytes Engage an Alternative Inflammasome Pathway., PMID:27037191 • D-mannose suppresses macrophage IL-1β production., PMID:33311467 • BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity., PMID:29324233 • Association of interleukin-6 and interleukin-1-β levels in patients with toxoplasmosis., PMID:35782407 • Interleukin-1 beta is significantly upregulated in the decidua of spontaneous and recurrent miscarriage placentas., PMID:33545613 • The effect of interleukin 1 beta blockade on the tumor microenvironment., PMID:33493144 • Single-cell profiling identifies IL1Bhi macrophages associated with inflammation in PD-1 inhibitor-induced inflammatory arthritis., PMID:38453911 |
| 别名 | 501081-76-1 |
| 备注 | For research use only. Not suitable for clinical or therapeutic use. |
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