Anti-Human Complement C2 Reference Antibody|抗人补体C2参考抗体(靶标：人补体C2)
- 货号：RB9THY106016
- 价格：面议
- 点击：561
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Human |
| 克隆性 | Monoclonal |
| 抗体亚型 | IgG1-kappa |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 浓度 | 1mg/ml |
| 内毒素水平 | Please contact the lab for this information. |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 种属反应性 | Human |
| 靶标 | Complement C2, C2, C3/C5 convertase |
| 储存缓冲液 | 0.01M PBS, pH 7.4. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 表达系统 | Mammalian Cells |
| 登录号 | P06681 |
| 背景信息 | Empasiprubar (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. Empasiprubar binds to the Sushi-2 domain of C2, preventing the formation of C3 pre convertase and inhibiting the activation of classical and lectin pathways upstream of C3 activation. Empasiprubar can prevent complement mediated autoimmune hemolytic anemia and antibody mediated organ transplant rejection. Empasiprubar can prevent neuroglial lymphoconjunctival injury in GM1 antibody mediated mouse models. • Granzyme K activates the entire complement cascade., PMID:39914456 • Granzyme K drives a newly-intentified pathway of complement activation., PMID:38826230 • Plasmin as a complement C5 convertase., PMID:27077104 • Inhibition of the alternative C3 convertase and classical C5 convertase of complement by group A streptococcal M protein., PMID:2142480 • Formation of high affinity C5 convertase of the classical pathway of complement., PMID:12878586 • The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation., PMID:19237749 • Modulation of classical C3 convertase of complement by tear lactoferrin., PMID:6922088 • Inhibition of c3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components., PMID:24983375 • MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway., PMID:9777418 • The human complement system: assembly of the classical pathway C3 convertase., PMID:6906228 |
| 别名 | 2579031-19-7 |
| 备注 | For research use only. Not suitable for clinical or therapeutic use. |
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