Research Grade Luspatercept|Luspatercept（研究用级别）(靶标：Luspatercept融合蛋白)
- 货号：RB9THF869016
- 价格：面议
- 点击：415
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 抗体亚型 | Fusion - [ACVR2B (activin A receptor type 2B, ActR |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 浓度 | 7mg/ml |
| 内毒素水平 | Please contact the lab for this information. |
| 应用 | ELISA, Functional assay, Research in vivo |
| 种属反应性 | Human |
| 靶标 | GDF11, BMP-11, BMP11, Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11 |
| 储存缓冲液 | 0.01M PBS, pH 7.4. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 表达系统 | Mammalian Cells |
| 登录号 | O95390 |
| 背景信息 | Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia. • GDF11: An emerging therapeutic target for liver diseases and fibrosis., PMID:38494851 • Neonatal Systemic AAV-Mediated Gene Delivery of GDF11 Inhibits Skeletal Muscle Growth., PMID:29503194 • GDF11/BMP11 activates both smad1/5/8 and smad2/3 signals but shows no significant effect on proliferation and migration of human umbilical vein endothelial cells., PMID:26919250 • GDF11 rapidly increases lipid accumulation in liver cancer cells through ALK5-dependent signaling., PMID:33684566 • Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11., PMID:10391213 • Induction of reparative dentin formation by ultrasound-mediated gene delivery of growth/differentiation factor 11., PMID:12718768 |
| 别名 | ACE-536, luspatercept–aamt, 1373715-00-4 |
| 备注 | For research use only. Not suitable for clinical or therapeutic use. |
相关产品:
| 产品名称 | 点击数 |
|---|---|
| CA-125单克隆抗体 | 7067 |
| PSA单克隆抗体 | 7144 |
| AFP单克隆抗体 | 7131 |
| CA-724单克隆抗体 | 7018 |
| CA-199单克隆抗体 | 6958 |
| HE4单克隆抗体 | 6825 |
| 孕酮单克隆抗体 | 7442 |
| 人胎球蛋白A(Fetuin A)单克隆抗体 | 7159 |
| 胎盘泌乳素单克隆抗体 | 7089 |
| 泌乳素单克隆抗体 | 6764 |
| SP-10单克隆抗体 | 6998 |
| AMH单克隆抗体 | 7310 |
| 胎儿纤维链接蛋白单克隆抗体 | 7152 |
| HCG单克隆抗体 | 7057 |
| 人骨碱性磷酸酶单克隆抗体 | 6829 |
| 小分子单克隆抗体 | 7183 |
| 抗环瓜氨酸肽抗体(Anti-CCP)诊断试剂原料 | 7007 |
| 耐碳青霉烯单克隆抗体 | 7161 |
| 补体C4c单克隆抗体 | 7346 |
| 补体C3c单克隆抗体 | 6874 |
