Research Grade Ramatercept|Ramatercept（研究用级别）(靶标：Ramatercept融合蛋白)
- 货号：RB9THT343066
- 价格：面议
- 点击：294
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 抗体亚型 | Fusion - [ACVR2B (activin A receptor type 2B, ActR |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 浓度 | 1.9mg/ml |
| 内毒素水平 | Please contact the lab for this information. |
| 应用 | ELISA, Functional assay, Research in vivo |
| 种属反应性 | Human |
| 靶标 | GDF-8, GDF8, MSTN, Myostatin, Growth/differentiation factor 8 |
| 储存缓冲液 | 0.01M PBS, pH 7.4. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 表达系统 | Mammalian Cells |
| 登录号 | O14793 |
| 背景信息 | Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy. • Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction., PMID:33938454 • Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member., PMID:9139826 • GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury., PMID:38019905 • Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells., PMID:25641196 • Growth differentiation factor myostatin regulates epithelial-mesenchymal transition genes and enhances invasion by increasing serine protease inhibitors E1 and E2 in human trophoblast cells., PMID:37738042 • Growth differentiation factor 8 induces SKOV3 ovarian cancer cell migration and E-cadherin down-regulation., PMID:27481097 • Circulating Growth Differentiation Factor 11/8 Levels Decline With Age., PMID:26489925 • Crystal structure of the WFIKKN2 follistatin domain reveals insight into how it inhibits growth differentiation factor 8 (GDF8) and GDF11., PMID:30814254 • Effects of growth differentiation factor 8 on steroidogenesis in human granulosa-lutein cells., PMID:26607022 • Molecular characterization of latent GDF8 reveals mechanisms of activation., PMID:29348202 |
| 别名 | ACE-031, ActRIIB-IgG1, ActRIIb:FcFusionProtein, HGT-4510, RAP-031, 1169766-01-1 |
| 备注 | For research use only. Not suitable for clinical or therapeutic use. |
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