Anti-Human Complement Component C1s Reference Antibody|抗人补体C1s参考抗体(靶标：人补体C1s)
- 货号：RB9THY598026
- 价格：面议
- 点击：262
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Human |
| 克隆性 | Monoclonal |
| 抗体亚型 | IgG4-kappa |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 浓度 | 1mg/ml |
| 内毒素水平 | Please contact the lab for this information. |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 种属反应性 | Human |
| 靶标 | C1 esterase, Complement C1s subcomponent, C1S, Complement component 1 subcomponent s |
| 储存缓冲液 | 0.01M PBS, pH 7.4. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 表达系统 | Mammalian Cells |
| 登录号 | P09871 |
| 背景信息 | Riliprubart (SAR445088) is an anti-C1s humanized monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system. Riliprubart selectively inhibits activated C1s and prevents the enzymatic action of C1 on its substrates C4 and C2, thus inhibiting the formation of the classical pathway C3 convertase, C4b2a. • Sutimlimab: First Approval., PMID:35412113 • Complement Component 1, s Subcomponent Overexpression is an Independent Poor Prognostic Indicator in Patients with Urothelial Carcinomas of the Upper Urinary Tract and Urinary Bladder., PMID:27471555 • Genetic studies of low-abundance human plasma proteins. VII. Heterogeneity of the C1S subcomponent of the first complement component., PMID:3331643 • Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation., PMID:23922389 • C1 inhibitor: different mechanisms of reaction with complement component C1 and C1s., PMID:2055603 • Fluid-phase interaction of C1 inhibitor (C1 Inh) and the subcomponents C1r and C1s of the first component of complement, C1., PMID:6282262 • Human complement component C1s. Partial sequence determination of the heavy chain and identification of the peptide bond cleaved during activation., PMID:3007145 • Is there a link between genetic defects in the complement cascade and Porphyromonas gingivalis in Alzheimer's disease?, PMID:31893014 • Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S, which Encode Subcomponents C1r and C1s of Complement., PMID:27745832 • Activation of the first component of human complement, C1, by monoclonal antibodies directed against different domains of subcomponent C1q., PMID:3486914 |
| 别名 | 2756228-76-7 |
| 备注 | For research use only. Not suitable for clinical or therapeutic use. |
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