Research Grade Cibotercept|Cibotercept（研究用级别）(靶标：Cibotercept融合蛋白)
- 货号：RB9THC570016
- 价格：面议
- 点击：177
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 抗体亚型 | Human ACTR-IIB extracellular domain (ECD) fragment |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 浓度 | 1mg/ml |
| 内毒素水平 | Please contact the lab for this information. |
| 应用 | ELISA, Functional assay, Research in vivo |
| 种属反应性 | Human |
| 靶标 | ACTR-IIB, Activin receptor type IIB, Activin receptor type-2B, ACVR2B |
| 储存缓冲液 | 0.01M PBS, pH 7.4. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 表达系统 | Mammalian Cells |
| 登录号 | Q13705 |
| 背景信息 | Cibotercept is an anti-MSTN/INHBA/GDF11 monoclonal antibody. • LncRNA ACVR2B-as1 interacts with ALDOA to regulate the self-renewal and apoptosis of human spermatogonial stem cells by controlling glycolysis activity., PMID:39254854 • Epistasis between polymorphisms in ACVR2B and ADAMTS19 is associated with premature ovarian failure., PMID:25051287 • ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass., PMID:29089584 • Activin A and Acvr2b mRNA from Umbilical Cord Blood Are Not Reliable Markers of Mild or Moderate Neonatal Hypoxic-Ischemic Encephalopathy., PMID:33706404 • Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B., PMID:26047946 • iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva., PMID:38500216 • BMPR2 inhibits activin and BMP signaling via wild-type ALK2., PMID:29739878 • Circ_0000566 contributes oxygen-glucose deprivation and reoxygenation (OGD/R)-induced human brain microvascular endothelial cell injury via regulating miR-18a-5p/ACVR2B axis., PMID:36781583 • Muscle and serum metabolomes are dysregulated in colon-26 tumor-bearing mice despite amelioration of cachexia with activin receptor type 2B ligand blockade., PMID:30860875 • Antibody-based strategies for the detection of Luspatercept (ACE-536) in human serum., PMID:28929587 |
| 别名 | 2769700-97-0 |
| 备注 | For research use only. Not suitable for clinical or therapeutic use. |
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