当前位置：首页>产品中心>单抗/多抗>Anti-Human 4-1BB/TNFRSF9/CD137& HER2 Bispecific Reference Antibody|抗人4-1BB/TNFRSF9/CD137和HER2双特异性参考抗体(靶标：人4-1BB/HER2)
Anti-Human 4-1BB/TNFRSF9/CD137& HER2 Bispecific Reference Antibody|抗人4-1BB/TNFRSF9/CD137和HER2双特异性参考抗体(靶标：人4-1BB/HER2)
- 货号：RB9THC336186
- 价格：面议
- 点击：193
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Human |
| 抗体亚型 | IgG |
| 纯度 | >95% purity as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 浓度 | 1mg/ml |
| 内毒素水平 | Please contact the lab for this information. |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 种属反应性 | Human |
| 靶标 | Bispecific, Tumor necrosis factor receptor superfamily member 9, CD137, 4-1BB ligand receptor, CDw137, TNFRSF9, T-cell antigen ILA, T-cell antigen 4-1BB homolog, ILA, p185erbB2, HER2, NGL, Tyrosine ki |
| 储存缓冲液 | 0.01M PBS, pH 7.4. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| 表达系统 | Mammalian Cells |
| 登录号 | Q07011 & P04626 |
| 背景信息 | Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB; Kd=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research. |
| 备注 | For research use only. Not suitable for clinical or therapeutic use. |
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