InVivoMAb anti-Mouse CTLA-4 Antibody|InVivoMAb抗小鼠CTLA-4抗体(靶标：小鼠细胞毒性T淋巴细胞相关蛋白4)
- 货号：RB9TMB651010
- 价格：面议
- 点击：165
产品介绍
产品参数
| 产品描述 | The Iv0047 monoclonal antibody specifically targets mouse CTLA-4 (CD152), a 33-kDa inhibitory receptor of the CD28 family expressed on activated T and B cells. CTLA-4 interacts with the B7 ligands CD80 and CD86, delivering negative signals that regulate T-cell activation, maintain immune tolerance, and preserve homeostasis. The critical role of CTLA-4 is underscored by CTLA-4–deficient mice, which develop lethal lymphoproliferation. As an important immune checkpoint, CTLA-4 is a key target for cancer immunotherapy. The 9D9 antibody is widely employed to block CTLA-4 and has been shown in multiple tumor models to effectively deplete intratumoral regulatory T cells in vivo. |
|---|---|
| 形态 | Liquid |
| 宿主种属 | Mouse |
| 克隆性 | Monoclonal |
| 抗体亚型 | IgG2b, kappa |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 浓度 | 1 mg/ml |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, Neutralization |
| 种属反应性 | Mouse |
| 靶标 | Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, Ctla4, Cd152 |
| 储存缓冲液 | 0.01M PBS, pH 7.4. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 登录号 | P09793 |
| 备注 | For research use only. Not suitable for clinical or therapeutic use. |
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