| 产品描述 | Iv0090 is a human IgG monoclonal antibody targeting CXCL12α, β, and γ. It blocks CXCL12 binding to CXCR4 and CXCR7 and inhibits CXCL12-driven cell migration in vitro. In vivo, Iv0090 significantly inhibits tumor growth and metastasis, reduces arthritis severity in mouse CIA models, and decreases laser-induced choroidal neovascularization by 50%. |
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| 形态 | Liquid |
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| 宿主种属 | Human |
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| 克隆性 | Monoclonal |
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| 抗体亚型 | IgG1, kappa |
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| 纯度 | >95% as determined by SDS-PAGE. |
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| 纯化方式 | Protein A/G purified from cell culture supernatant. |
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| 浓度 | 2.07 mg/ml |
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| 内毒素水平 | Please contact with the lab for this information. |
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| 应用 | ELISA, Neutralization |
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| 种属反应性 | Human |
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| 靶标 | Intercrine reduced in hepatomas, hSDF-1, Stromal cell-derived factor 1, SDF-1, Pre-B cell growth-stimulating factor, SDF1, SDF1A, C-X-C motif chemokine 12, SDF1B, CXCL12, IRH, PBSF, hIRH |
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| 储存缓冲液 | 0.01M PBS, pH 7.4. |
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| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
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| 登录号 | P48061 |
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| 备注 | For research use only. Not suitable for clinical or therapeutic use. |
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