Anti-Mouse CD28 Recombinant Antibody|抗小鼠CD28重组抗体(靶标：小鼠CD28分子)
- 货号：RB9TMY422023
- 价格：面议
- 点击：452
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Armenian hamster |
| 克隆性 | Monoclonal |
| 抗体亚型 | IgG |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, FACS, Functional assay, Research in vivo, in vitro T cell stimulation/activation |
| 种属反应性 | Mouse |
| 靶标 | CD28, Cd28, T-cell-specific surface glycoprotein CD28 |
| 储存缓冲液 | 0.01M PBS pH 7.4 |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重构方法 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 产品使用说明 | ELISA: 1:2000-1:20000 |
| 登录号 | P31041 |
| 背景信息 | T-cell-specific surface glycoprotein CD28 is a ~25 kDa protein. Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis. Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells. Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets. Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways. In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells. 1. Shahinian, A. et al. (1993) Science (New York, N.Y.) 261, 609-12. PMID: 7688139 |
| 备注 | For research use only |
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