当前位置：首页>产品中心>单抗/多抗>Anti-Mouse CCR3/CD193 Recombinant Antibody|抗小鼠CCR3/CD193重组抗体(靶标：小鼠CC趋化因子受体3/CD193)
Anti-Mouse CCR3/CD193 Recombinant Antibody|抗小鼠CCR3/CD193重组抗体(靶标：小鼠CC趋化因子受体3/CD193)
- 货号：RB9TMW620013
- 价格：面议
- 点击：245
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rat |
| 克隆性 | Monoclonal |
| 抗体亚型 | IgG2b, kappa |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 内毒素水平 | <1 EU/mg |
| 应用 | ELISA, FACS, Functional assay, Research in vivo |
| 种属反应性 | Mouse |
| 靶标 | C C CKR3, C-C CKR-3, C-C chemokine receptor type 3, CC-CKR-3, CCR-3, CCR3, CD193, CKR 3, CKR3, CMKBR3, Eosinophil eotaxin receptor |
| 储存缓冲液 | 0.01M PBS pH 7.4 |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 运输条件 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 产品使用说明 | ELISA: 1:2000-1:20000 |
| 登录号 | P51678 |
| 背景信息 | Probable C-C chemokine receptor type 3 (CCR3/CD193) is a ~41 kDa protein. G protein-coupled receptor (GPCR) that plays a key role in the immune system by regulating the migration and activation of white blood cells in response to chemokines. Selectively interacts with eosinophil-attracting chemokines such as eotaxin/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. Ligand binding triggers intracellular signaling that leads to chemotaxis of immune cells. Mechanistically, signals through GNA14 or GNA16 to induce stimulation of phospholipase Cbeta/PLCB2 and subsequently chemotaxis. Alternatively, transduces signal via GNAI1 resulting in elevated intracellular calcium levels and activation of the PI3K/AKT pathway. |
| 备注 | For research use only |
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