Anti-Mouse TIGIT Recombinant Antibody|抗小鼠TIGIT重组抗体(靶标：小鼠T细胞免疫球蛋白和ITIM结构域蛋白)
- 货号：RB9TMS739023
- 价格：面议
- 点击：188
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Mouse |
| 克隆性 | Monoclonal |
| 抗体亚型 | IgG1, kappa |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, FACS, Functional assay, Research in vivo |
| 种属反应性 | Mouse |
| 靶标 | T-cell immunoreceptor with Ig and ITIM domains, Tigit, V-set and transmembrane domain-containing protein 3, Vstm3 |
| 储存缓冲液 | 0.01M PBS pH 7.4 |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重构方法 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 产品使用说明 | ELISA: 1:2000-1:20000 |
| 登录号 | P86176 |
| 背景信息 | T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a ~26 kDa protein. Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades. |
| 备注 | For research use only |
相关产品: