当前位置：首页>产品中心>单抗/多抗>Anti-Human CD117/KIT Recombinant Antibody|抗人CD117/KIT重组抗体(靶标：人KIT原癌基因受体酪氨酸激酶/CD117)
Anti-Human CD117/KIT Recombinant Antibody|抗人CD117/KIT重组抗体(靶标：人KIT原癌基因受体酪氨酸激酶/CD117)
- 货号：RB9THY163013
- 价格：面议
- 点击：236
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Mouse |
| 克隆性 | Monoclonal |
| 抗体亚型 | IgG2a, kappa |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, FACS, Functional assay, Research in vivo |
| 种属反应性 | Human |
| 靶标 | CD117, EC:2.7.10.1, KIT, Mast/stem cell growth factor receptor Kit, PBT, Piebald trait protein, Proto-oncogene c-Kit, SCFR, Tyrosine-protein kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarc |
| 储存缓冲液 | 0.01M PBS pH 7.4 |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 产品使用说明 | ELISA: 1:2000-1:20000 |
| 登录号 | P10721 |
| 背景信息 | Mast/stem cell growth factor receptor Kit (CD117) is a ~109 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. |
| 备注 | For research use only |
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