Anti-Mouse IFNG/IFN-gamma Polyclonal Antibody|抗小鼠IFNG/IFN-γ多克隆抗体(靶标：小鼠干扰素γ)
- 货号：RB9TMF813014
- 价格：面议
- 点击：219
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse |
| 靶标 | IFN-gamma, Ifng, Interferon gamma |
| 免疫原 | E. coli - derived recombinant mouse IFNG/IFN-gamma (His23-Cys155). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P01580 |
| 背景信息 | Interferon gamma is a ~17 kDa protein. Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. 1. Pearl, JE. et al. (2001) Cellular immunology 211, 43-50. PMID: 11585387 2. Huang, S. et al. (1993) Science (New York, N.Y.) 259, 1742-5. PMID: 8456301 3. Baldridge, MT. et al. (2010) Nature 465, 793-7. PMID: 20535209 4. Matatall, KA. et al. (2014) Stem cells (Dayton, Ohio) 32, 3023-30. PMID: 25078851 |
| 备注 | For research use only |
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