Anti-Human KRAS Recombinant Nanobody (SBT-100)|抗人KRAS纳米抗体(靶标：人KRAS原癌基因)
- 货号：RB9THF904023
- 价格：面议
- 点击：464
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Alpaca |
| 克隆性 | Monoclonal |
| 抗体亚型 | VHH-His |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Purified by Nickel column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IF |
| 种属反应性 | Human |
| 靶标 | EC:3.6.5.2, GTPase KRas, GTPase KRas, N-terminally processed, K-Ras 2, KRAS, KRAS2, Ki-Ras, RASK2, c-K-ras, c-Ki-ras |
| 储存缓冲液 | 0.01M PBS pH 7.4 |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 产品使用说明 | ELISA: 1:2000-1:20000 |
| 登录号 | P01116 |
| 背景信息 | GTPase KRas is a ~21 kDa protein. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. 1. Gremer, L. et al. (2011) Human mutation 32, 33-43. PMID: 20949621 2. Bernal Astrain, G. et al. (2025) Nature communications 16, 647. PMID: 39809765 3. Yang, MH. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 10843-8. PMID: 22711838 4. Zimmermann, G. et al. (2013) Nature 497, 638-42. PMID: 23698361 5. Serra, RW. et al. (2014) eLife 3, e02313. PMID: 24623306 |
| 备注 | For research use only |
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