当前位置：首页>产品中心>单抗/多抗>Anti-Human TRAIL R2/TNFRSF10B Reference Antibody|抗人TRAIL R2/TNFRSF10B参照抗体(靶标：人肿瘤坏死因子受体超家族成员10B/TRAIL-R2(研究用))
Anti-Human TRAIL R2/TNFRSF10B Reference Antibody|抗人TRAIL R2/TNFRSF10B参照抗体(靶标：人肿瘤坏死因子受体超家族成员10B/TRAIL-R2(研究用))
- 货号：RB9THT348156
- 价格：面议
- 点击：180
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Human |
| 克隆性 | Monoclonal |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 内毒素水平 | < 10 EU/mg |
| 应用 | ELISA, FACS, Functional assay |
| 种属反应性 | Human |
| 靶标 | CD262, DR5, Death receptor 5, KILLER, TNF-related apoptosis-inducing ligand receptor 2, TNFRSF10B, TRAIL receptor 2, TRAIL-R2, TRAILR2, TRICK2, Tumor necrosis factor receptor superfamily member 10B, Z |
| 储存缓冲液 | 0.01M PBS pH 7.4 |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 产品使用说明 | ELISA: 1:2000-1:20000 |
| 登录号 | O14763 |
| 背景信息 | Tumor necrosis factor receptor superfamily member 10B (DR5) is a ~47 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. 1. Hymowitz, SG. et al. (1999) Molecular cell 4, 563-71. PMID: 10549288 |
| 备注 | For research use only. |
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