当前位置：首页>产品中心>单抗/多抗>Anti-Human TRAIL R2/TNFRSF10B Reference Antibody|抗人TRAIL R2/TNFRSF10B参照抗体(靶标：人肿瘤坏死因子受体超家族成员10B/TRAIL-R2(研究用))

Anti-Human TRAIL R2/TNFRSF10B Reference Antibody|抗人TRAIL R2/TNFRSF10B参照抗体(靶标：人肿瘤坏死因子受体超家族成员10B/TRAIL-R2(研究用))

形态	Liquid
宿主种属	Human
克隆性	Monoclonal
纯度	>95% as determined by SDS-PAGE.
纯化方式	Protein A/G purified from cell culture supernatant.
内毒素水平	< 10 EU/mg
应用	ELISA, FACS, Functional assay
种属反应性	Human
靶标	CD262, DR5, Death receptor 5, KILLER, TNF-related apoptosis-inducing ligand receptor 2, TNFRSF10B, TRAIL receptor 2, TRAIL-R2, TRAILR2, TRICK2, Tumor necrosis factor receptor superfamily member 10B, Z
储存缓冲液	0.01M PBS pH 7.4
稳定性和储存	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
产品使用说明	ELISA: 1:2000-1:20000
登录号	O14763
背景信息	Tumor necrosis factor receptor superfamily member 10B (DR5) is a ~47 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. 1. Hymowitz, SG. et al. (1999) Molecular cell 4, 563-71. PMID: 10549288
备注	For research use only.

【仅供科学研究使用】

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