InVivoMAb anti-Mouse TIM-3 Antibody|InVivoMAb抗小鼠TIM-3抗体(靶标：小鼠T细胞免疫球蛋白和黏蛋白结构域蛋白3)
- 货号：RB9TMV029010
- 价格：面议
- 点击：310
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rat |
| 克隆性 | Monoclonal |
| 抗体亚型 | IgG1, kappa |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 内毒素水平 | < 10 EU/mg |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 种属反应性 | Mouse |
| 靶标 | CD366, HAVcr-2, Havcr2, Hepatitis A virus cellular receptor 2 homolog, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, T |
| 储存缓冲液 | 0.01M PBS pH 7.4 |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 产品使用说明 | ELISA: 1:2000-1:20000 |
| 登录号 | Q8VIM0 |
| 背景信息 | Hepatitis A virus cellular receptor 2 homolog (CD366/HAVCR2) is a ~30 kDa protein. Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. 1. Anderson, AC. et al. (2007) Science (New York, N.Y.) 318, 1141-3. PMID: 18006747 2. Monney, L. et al. (2002) Nature 415, 536-41. PMID: 11823861 3. Sabatos, CA. et al. (2003) Nature immunology 4, 1102-10. PMID: 14556006 4. Lee, J. et al. (2011) Molecular and cellular biology 31, 3963-74. PMID: 21807895 5. Rangachari, M. et al. (2012) Nature medicine 18, 1394-400. PMID: 22863785 6. Jayaraman, P. et al. (2010) The Journal of experimental medicine 207, 2343-54. PMID: 20937702 7. Gorman, JV. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 3133-42. PMID: 24567532 8. DeKruyff, RH. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 184, 1918-30. PMID: 20083673 9. Nakayama, M. et al. (2009) Blood 113, 3821-30. PMID: 19224762 |
| 备注 | For research use only. |
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