| 形态 | Liquid |
|---|---|
| 宿主种属 | Human |
| 克隆性 | Monoclonal |
| 抗体亚型 | IgG3, kappa |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IF, Bioactivity: FACS, Functional assay, Research in vivo |
| 种属反应性 | Homo sapiens (Human) |
| 靶标 | CFH, Complement factor H, H factor 1, HF, HF1, HF2 |
| 储存缓冲液 | 0.01M PBS pH 7.4 |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重构方法 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输条件 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 登录号 | P08603 |
| 背景信息 | Complement factor H (CFH) is a ~139 kDa protein. Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. 1. Kajander, T. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2897-902. PMID: 21285368 2. Morgan, HP. et al. (2011) Nature structural & molecular biology 18, 463-70. PMID: 21317894 3. Blaum, BS. et al. (2015) Nature chemical biology 11, 77-82. PMID: 25402769 4. Wu, J. et al. (2009) Nature immunology 10, 728-33. PMID: 19503104 5. Kennedy, AT. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 196, 1239-48. PMID: 26700768 6. Hocking, HG. et al. (2008) The Journal of biological chemistry 283, 9475-87. PMID: 18252712 7. Simon, N. et al. (2013) Cell host & microbe 13, 29-41. PMID: 23332154 8. Xue, X. et al. (2017) Nature structural & molecular biology 24, 643-651. PMID: 28671664 9. Losse, J. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 184, 912-21. PMID: 20008295 10. DiScipio, RG. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 4057-66. PMID: 9558116 |
| 备注 | For research use only |
| 产品名称 | 点击数 |
|---|---|
| CA-125单克隆抗体 | 6955 |
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| AFP单克隆抗体 | 7025 |
| CA-724单克隆抗体 | 6947 |
| CA-199单克隆抗体 | 6859 |
| HE4单克隆抗体 | 6716 |
| 孕酮单克隆抗体 | 7346 |
| 人胎球蛋白A(Fetuin A)单克隆抗体 | 7104 |
| 胎盘泌乳素单克隆抗体 | 6961 |
| 泌乳素单克隆抗体 | 6703 |
| SP-10单克隆抗体 | 6868 |
| AMH单克隆抗体 | 7243 |
| 胎儿纤维链接蛋白单克隆抗体 | 7044 |
| HCG单克隆抗体 | 6955 |
| 人骨碱性磷酸酶单克隆抗体 | 6762 |
| 小分子单克隆抗体 | 7055 |
| 抗环瓜氨酸肽抗体(Anti-CCP)诊断试剂原料 | 6937 |
| 耐碳青霉烯单克隆抗体 | 7065 |
| 补体C4c单克隆抗体 | 7297 |
| 补体C3c单克隆抗体 | 6840 |