当前位置：首页>产品中心>单抗/多抗>Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody|抗人/小鼠/大鼠GPX4单克隆抗体(靶标：人/小鼠/大鼠谷胱甘肽过氧化物酶4)
Anti-Human/Mouse/Rat GPX4 Monoclonal Antibody|抗人/小鼠/大鼠GPX4单克隆抗体(靶标：人/小鼠/大鼠谷胱甘肽过氧化物酶4)
- 货号：RB9THW551015
- 价格：面议
- 点击：541
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Mouse |
| 克隆性 | Monoclonal |
| 抗体亚型 | IgG2b |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, WB |
| 种属反应性 | Human, Mouse, Rat |
| 靶标 | EC:1.11.1.12, EC:1.11.1.9, GPX4, GPx-4, GSHPx-4, Glutathione peroxidase 4, PHGPx, Phospholipid hydroperoxide glutathione peroxidase GPX4 |
| 免疫原 | E. coli - derived recombinant rat GPX4 (Gly73-Leu196). |
| 储存缓冲液 | 0.01M PBS, pH 7.4. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重构方法 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 登录号 | P36970 |
| 观测分子量 | 20 kDa |
| 背景信息 | Phospholipid hydroperoxide glutathione peroxidase (GPX4) is a ~22 kDa protein. Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide. Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis. 1. Roveri, A. et al. (1992) The Journal of biological chemistry 267, 6142-6. PMID: 1556123 2. Arai, M. et al. (1999) The Journal of biological chemistry 274, 4924-33. PMID: 9988735 |
| 备注 | For research use only |
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