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Anti-Human ANGPTL4 Reference Antibody|抗人ANGPTL4参照抗体(靶标:人血管生成素样蛋白4(研究用))

  • 货号:RB9THV344016
  • 价格:面议
  • 点击:277

产品介绍

产品参数

形态Liquid
宿主种属Human
克隆性Monoclonal
抗体亚型IgG1, kappa
纯度>95% as determined by SDS-PAGE.
纯化方式Protein A/G purified from cell culture supernatant.
内毒素水平< 10 EU/mg
应用ELISA, Bioactivity: FACS, Functional assay, Research in vivo
种属反应性Human
储存缓冲液0.01 M PBS pH 7.4
稳定性和储存Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -123°C long term.
产品使用说明ELISA: 1:2000-1:20000
登录号Q9BY76
背景信息

Angiopoietin-related protein 4 (ANGPTL4) is a ~45 kDa protein. Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro). Depending on context, may modulate tumor-related angiogenesis.

1. Yin, W. et al. (2009) The Journal of biological chemistry 284, 13213-22. PMID: 19270337
2. Lei, X. et al. (2011) The Journal of biological chemistry 286, 15747-56. PMID: 21398697
3. Mysling, S. et al. (2016) eLife 5. PMID: 27929370
4. Kristensen, KK. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E6020-E6029. PMID: 29899144
5. Ito, Y. et al. (2003) Cancer research 63, 6651-7. PMID: 14583458
6. Cazes, A. et al. (2006) Circulation research 99, 1207-15. PMID: 17068295
备注For research use only.
【仅供科学研究使用】

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