| 形态 | Liquid |
|---|---|
| 宿主种属 | Human |
| 克隆性 | Monoclonal |
| 抗体亚型 | IgG1, kappa |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 内毒素水平 | < 10 EU/mg |
| 应用 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 种属反应性 | Human |
| 储存缓冲液 | 0.01 M PBS pH 7.4 |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -123°C long term. |
| 产品使用说明 | ELISA: 1:2000-1:20000 |
| 登录号 | Q9BY76 |
| 背景信息 | Angiopoietin-related protein 4 (ANGPTL4) is a ~45 kDa protein. Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro). Depending on context, may modulate tumor-related angiogenesis. 1. Yin, W. et al. (2009) The Journal of biological chemistry 284, 13213-22. PMID: 19270337 2. Lei, X. et al. (2011) The Journal of biological chemistry 286, 15747-56. PMID: 21398697 3. Mysling, S. et al. (2016) eLife 5. PMID: 27929370 4. Kristensen, KK. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E6020-E6029. PMID: 29899144 5. Ito, Y. et al. (2003) Cancer research 63, 6651-7. PMID: 14583458 6. Cazes, A. et al. (2006) Circulation research 99, 1207-15. PMID: 17068295 |
| 备注 | For research use only. |
| 产品名称 | 点击数 |
|---|---|
| NGAL单克隆抗体 | 7684 |
| 白细胞介素6(IL-6)单克隆抗体 | 7376 |
| 肝素结合蛋白单克隆抗体 | 6853 |
| CRP单克隆抗体 | 7682 |
| 猫胰脂肪酶单克隆抗体 | 7198 |
| 马SAA单克隆抗体 | 7582 |
| 犬腺病毒单克隆抗体 | 6923 |
| 犬轮状病毒单克隆抗体 | 7008 |
| 犬血红蛋白单克隆抗体 | 7977 |
| 犬胰脂肪酶单克隆抗体 | 6814 |
| 犬松弛素单克隆抗体 | 7179 |
| 犬冠状病毒单克隆抗体 | 7194 |
| 犬瘟病毒单克隆抗体 | 6904 |
| 犬细小病毒单克隆抗体 | 7356 |
| 猫瘟病毒单克隆抗体 | 7485 |
| 猫疱疹病毒单克隆抗体 | 7231 |
| 猫杯状病毒单克隆抗体 | 7654 |
| 猫SAA单克隆抗体 | 7294 |
| 犬CRP单克隆抗体 | 7826 |
| 犬、猫IgG单克隆抗体 | 7174 |