Anti-Human IL2 Recombinant Antibody |抗人IL2重组抗体(靶标：人白细胞介素2)
- 货号：RB9THX061013
- 价格：面议
- 点击：302
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Human |
| 克隆性 | Monoclonal |
| 抗体亚型 | scFv-hFc |
| 纯度 | >95% as determined by SDS-PAGE. |
| 纯化方式 | Protein A/G purified from cell culture supernatant. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, in vivo and in vitro study |
| 种属反应性 | Homo sapiens (Human) |
| 靶标 | Aldesleukin, IL-2, IL2, Interleukin-2, T-cell growth factor, TCGF |
| 储存缓冲液 | 0.01M PBS pH 7.4 |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重构方法 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输条件 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 登录号 | P60568 |
| 背景信息 | Interleukin-2 (IL2) is a ~17 kDa protein. Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. 1. Mingari, MC. et al. (1984) Nature 312, 641-3. PMID: 6438535 2. Wang, X. et al. (2005) Science (New York, N.Y.) 310, 1159-63. PMID: 16293754 3. Stauber, DJ. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 2788-93. PMID: 16477002 4. Miyazaki, T. et al. (1994) Science (New York, N.Y.) 266, 1045-7. PMID: 7973659 5. Kirken, RA. et al. (1995) Cytokine 7, 689-700. PMID: 8580378 6. Osinalde, N. et al. (2015) Proteomics 15, 520-31. PMID: 25142963 7. Holbrook, NJ. et al. (1984) Proceedings of the National Academy of Sciences of the United States of America 81, 1634-8. PMID: 6608729 |
| 备注 | For research use only |
相关产品:
| 产品名称 | 点击数 |
|---|---|
| 炔诺酮单抗 | 6052 |
| 磺胺氯吡嗪单抗 | 6037 |
| 呋喃苯烯酸钠单抗 | 5778 |
| 呋喃它酮代谢物（2-NPAMOZ）单抗 | 5815 |
| 呋喃西林代谢物（2-NPSEM）单抗 | 5616 |
| 磺胺喹恶啉单抗 | 5923 |
| 苯丙酸诺龙单抗 | 5833 |
| 司帕沙星单抗 | 5647 |
| 妥布霉素单抗 | 5823 |
| 甲氧氯普胺单抗 | 5645 |
| 莫能菌素单抗 | 5832 |
| 多粘菌素B（粘菌素）单抗 | 6147 |
| 磺胺类单抗 | 6090 |
| 托灭酸（托芬那酸）单抗 | 5663 |
| 卡洛芬单抗 | 5626 |
| 喹乙醇代谢物MQCA单抗 | 5759 |
| 氟尼辛单抗 | 5829 |
| 磺胺二甲嘧啶（SM2）单抗 | 5517 |
| 诺龙（19-去甲睾酮）单抗 | 5634 |
| 阿苯达唑-2-氨基砜单抗 | 5561 |
