Anti-FBXW7 Polyclonal Antibody|抗FBXW7多克隆抗体(靶标：F-box和WD重复结构域含蛋白7)
- 货号：RB9THP138014
- 价格：面议
- 点击：475
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Mouse, Rat, Bovine |
| 靶标 | Archipelago homolog, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, F-box/WD repeat-containing protein 7, FBW7, FBX30, FBXW7, SEL-10, SEL10, hAgo, hCdc4 |
| 免疫原 | E. coli - derived recombinant human FBXW7 (Asp279-Val515). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 稳定性和储存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重构方法 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 运输条件 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q969H0 |
| 观测分子量 | 100 kDa |
| 背景信息 | F-box/WD repeat-containing protein 7 (FBXW7) is a ~79 kDa protein. Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NFE2L1, NOTCH2, MCL1, MLST8, RICTOR, and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation. Involved in bone homeostasis and negative regulation of osteoclast differentiation. 1. Hao, B. et al. (2007) Molecular cell 26, 131-43. PMID: 17434132 2. Duda, DM. et al. (2012) Molecular cell 47, 371-82. PMID: 22748924 3. Gorelik, M. et al. (2016) Proceedings of the National Academy of Sciences of the United States of America 113, 3527-32. PMID: 26976582 4. Yalla, K. et al. (2018) Molecular psychiatry 23, 1278-1286. PMID: 28727686 5. Zhang, E. et al. (2022) Cancer science 113, 91-108. PMID: 34741373 6. Stephenson, SEM. et al. (2022) American journal of human genetics 109, 601-617. PMID: 35395208 7. Zhang, Q. et al. (2016) Molecular cell 61, 419-433. PMID: 26774286 |
| 备注 | For research use only |
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