当前位置:首页>产品中心>单抗/多抗>Anti-Lassa virus/LASV Protein Z Polyclonal Antibody|抗拉沙病毒/LASV Z蛋白多克隆抗体(靶标:拉沙病毒Z蛋白)

Anti-Lassa virus/LASV Protein Z Polyclonal Antibody|抗拉沙病毒/LASV Z蛋白多克隆抗体(靶标:拉沙病毒Z蛋白)

  • 货号:RB9TVK810054
  • 价格:面议
  • 点击:416
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产品介绍

产品参数

形态Liquid
宿主种属Rabbit
克隆性Polyclonal
抗体亚型IgG
纯化方式Purified by antigen affinity column.
内毒素水平Please contact with the lab for this information.
应用ELISA, IHC, WB
种属反应性Lassa virus
靶标Protein Z, RING finger protein Z, Z, Zinc-binding protein
免疫原E. coli - derived recombinant Lassa virus/LASV Protein Z (Gly2-Pro99).
储存缓冲液0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
产品使用说明ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
登录号O73557
背景信息

RING finger protein Z is a ~10 kDa protein. Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L. Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z.

1. Strecker, T. et al. (2003) Journal of virology 77, 10700-5. PMID: 12970458
2. Cornu, TI. et al. (2004) Journal of virology 78, 2979-83. PMID: 14990716
备注For research use only
【仅供科学研究使用】

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