Anti-Mouse IL5 Polyclonal Antibody|抗小鼠IL5多克隆抗体(靶标：小鼠白细胞介素5)
- 货号：RB9TMY218014
- 价格：面议
- 点击：274
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Rat, Mouse |
| 靶标 | B-cell growth factor II, BCGF-II, Cytotoxic T-lymphocyte inducer, Eosinophil differentiation factor, IL-5, Il-5, Il5, Interleukin-5, T-cell replacing factor, TRF |
| 免疫原 | E. coli - derived recombinant Mouse IL5 (Met21-Gly133). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P04401 |
| 背景信息 | Interleukin-5 (IL5) is a ~15 kDa protein. Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Also acts on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively. IL5 is the therapeutic target of mepolizumab (Nucala). 1. Vallance, BA. et al. (1999) The American journal of physiology 277, G400-8. PMID: 10444455 2. Barry, SC. et al. (1991) Cytokine 3, 339-44. PMID: 1873482 3. Karasuyama, H. et al. (1988) The Journal of experimental medicine 167, 1377-90. PMID: 3128631 |
| 备注 | For research use only |
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