Anti-Rat CASR Polyclonal Antibody|抗大鼠CASR多克隆抗体(靶标：大鼠钙敏感受体)
- 货号：RB9TRW613014
- 价格：面议
- 点击：425
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Rat, Mouse |
| 靶标 | CaSR, Casr, Extracellular calcium-sensing receptor, Gprc2a, PCaR1, Parathyroid cell calcium-sensing receptor, Pcar1, RaKCaR |
| 免疫原 | E. coli - derived recombinant Rat CASR (Lys863-Ser1079). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P48442 |
| 背景信息 | Extracellular calcium-sensing receptor (CASR) is a ~120 kDa protein. G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration: activated by elevated circulating calcium, leading to decreased parathyroid hormone (PTH) secretion in parathyroid glands. In kidneys, acts as a key regulator of renal tubular calcium resorption. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G-proteins) and modulates the activity of downstream effectors. CASR is coupled with different G(q)/G(11), G(i)/G(o)- or G(s)-classes of G-proteins depending on the context. 1. Loupy, A. et al. (2012) The Journal of clinical investigation 122, 3355-67. PMID: 22886306 2. Riccardi, D. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 131-5. PMID: 7816802 |
| 备注 | For research use only |
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