| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | HKE4, Histidine-rich membrane protein Ke4, RING5, Really interesting new gene 5 protein, SLC39A7, Solute carrier family 39 member 7, ZIP7, Zinc transporter SLC39A7, Zrt-, Irt-like protein 7 |
| 免疫原 | E. coli - derived recombinant Human SLC39A7 (Gly30-Thr133). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q92504 |
| 背景信息 | Zinc transporter SLC39A7 is a ~50 kDa protein. Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels. Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation. Has an essential role in B cell development and is required for proper B cell receptor signaling. Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function. Controls cell signaling pathways involved in glucose metabolism in skeletal muscle. 1. Taylor, KM. et al. (2004) The Biochemical journal 377, 131-9. PMID: 14525538 2. Huang, L. et al. (2005) The Journal of biological chemistry 280, 15456-63. PMID: 15705588 3. Nimmanon, T. et al. (2017) Metallomics : integrated biometal science 9, 471-481. PMID: 28205653 4. Woodruff, G. et al. (2018) Molecular pharmacology 94, 1092-1100. PMID: 29980658 5. Taylor, KM. et al. (2012) Science signaling 5, ra11. PMID: 22317921 6. Anzilotti, C. et al. (2019) Nature immunology 20, 350-361. PMID: 30718914 7. Fauster, A. et al. (2019) Cell death and differentiation 26, 1138-1155. PMID: 30237509 |
| 备注 | For research use only |
| 产品名称 | 点击数 |
|---|---|
| 空肠弯曲菌单克隆抗体 | 7576 |
| 人触珠蛋白单克隆抗体 | 7807 |
| 贾第鞭毛虫单克隆抗体 | 7433 |
| 阿米巴单克隆抗体 | 8026 |
| 胃蛋白酶单克隆抗体 | 7474 |
| 胃蛋白酶原II单克隆抗体 | 7741 |
| 胃蛋白酶原I单克隆抗体 | 7416 |
| 艰难梭菌毒素A单克隆抗体 | 7576 |
| 艰难梭菌毒素B单克隆抗体 | 7904 |
| 艰难梭菌GDH单克隆抗体 | 7869 |
| 诺如病毒单克隆抗体 | 7368 |
| 伤寒沙门氏菌单克隆抗体 | 7442 |
| 鼠疫耶尔森菌F1单克隆抗体 | 6941 |
| 幽门螺杆菌单克隆抗体 | 7483 |
| 钙卫蛋白单克隆抗体 | 7234 |
| 乳铁蛋白单克隆抗体 | 7618 |
| 转铁蛋白单克隆抗体 | 7611 |
| 血红蛋白单克隆抗体 | 7303 |
| 腺病毒单克隆抗体 | 7553 |
| 轮状病毒单克隆抗体 | 7978 |