| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | HKE4, Histidine-rich membrane protein Ke4, RING5, Really interesting new gene 5 protein, SLC39A7, Solute carrier family 39 member 7, ZIP7, Zinc transporter SLC39A7, Zrt-, Irt-like protein 7 |
| 免疫原 | E. coli - derived recombinant Human SLC39A7 (Gly30-Thr133). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q92504 |
| 背景信息 | Zinc transporter SLC39A7 is a ~50 kDa protein. Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels. Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation. Has an essential role in B cell development and is required for proper B cell receptor signaling. Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function. Controls cell signaling pathways involved in glucose metabolism in skeletal muscle. 1. Taylor, KM. et al. (2004) The Biochemical journal 377, 131-9. PMID: 14525538 2. Huang, L. et al. (2005) The Journal of biological chemistry 280, 15456-63. PMID: 15705588 3. Nimmanon, T. et al. (2017) Metallomics : integrated biometal science 9, 471-481. PMID: 28205653 4. Woodruff, G. et al. (2018) Molecular pharmacology 94, 1092-1100. PMID: 29980658 5. Taylor, KM. et al. (2012) Science signaling 5, ra11. PMID: 22317921 6. Anzilotti, C. et al. (2019) Nature immunology 20, 350-361. PMID: 30718914 7. Fauster, A. et al. (2019) Cell death and differentiation 26, 1138-1155. PMID: 30237509 |
| 备注 | For research use only |
| 产品名称 | 点击数 |
|---|---|
| 倍硫磷单抗 | 6306 |
| 多菌灵/阿苯达唑二合一单抗 | 6380 |
| 三氯噻嗪单抗 | 6471 |
| 吡唑醚菌酯单抗 | 6691 |
| 烯酰吗啉单抗 | 6509 |
| 抑霉唑单抗 | 6233 |
| 恶醚唑(苯醚甲环唑)单抗 | 6409 |
| 赛拉嗪(甲苯噻嗪)单抗 | 6425 |
| 辛硫磷单抗 | 6500 |
| 多效唑单抗 | 6371 |
| 对硫磷单抗 | 6569 |
| 丙溴磷单抗 | 6613 |
| 戊唑醇单抗 | 6610 |
| 莠去津单抗 | 6483 |
| 灭蝇胺单抗 | 6177 |
| 尼卡巴嗪代谢物(DNC)单抗 | 6465 |
| 2.4-二氯苯氧乙酸单抗 | 6310 |
| 甲基对硫磷单抗 | 6389 |
| 左旋咪唑单抗 | 6324 |
| 三唑磷单抗 | 6399 |