当前位置：首页>产品中心>单抗/多抗>Anti-Human MAPT/Tau/PHF-tau Polyclonal Antibody|抗人MAPT/Tau/PHF-tau多克隆抗体(靶标：人微管相关蛋白Tau/成对螺旋丝-tau)
Anti-Human MAPT/Tau/PHF-tau Polyclonal Antibody|抗人MAPT/Tau/PHF-tau多克隆抗体(靶标：人微管相关蛋白Tau/成对螺旋丝-tau)
- 货号：RB9THY086044
- 价格：面议
- 点击：310
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Rat, Mouse |
| 靶标 | MAPT, MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau, TAU |
| 免疫原 | E. coli - derived recombinant Human MAPT/Tau/PHF-tau (Gln561-Glu689). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P10636 |
| 背景信息 | Microtubule-associated protein tau (MAPT/PHF-tau) is a ~78 kDa protein. Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. 1. Yoshida, H. et al. (2012) Journal of neurochemistry 120, 165-76. PMID: 21985311 2. Sandberg, A. et al. (2020) Neurobiology of disease 146, 105079. PMID: 32961270 |
| 备注 | For research use only |
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