Anti-Human CEP63 Polyclonal Antibody|抗人CEP63多克隆抗体(靶标：人中心体蛋白63)
- 货号：RB9THD664014
- 价格：面议
- 点击：256
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | CEP63, Centrosomal protein of 63 kDa, Cep63 |
| 免疫原 | E. coli - derived recombinant Human CEP63 (Met1-Ile309). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q96MT8 |
| 背景信息 | Centrosomal protein of 63 kDa (CEP63) is a ~81 kDa protein. Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. 1. Löffler, H. et al. (2011) Cancer research 71, 2129-39. PMID: 21406398 2. Sir, JH. et al. (2011) Nature genetics 43, 1147-53. PMID: 21983783 3. Kodani, A. et al. (2015) eLife 4. PMID: 26297806 4. Kodani, A. et al. (2022) EMBO reports 23, e52211. PMID: 35793002 5. Ling, H. et al. (2022) Oncogene 41, 4433-4445. PMID: 35989368 |
| 备注 | For research use only |
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