Anti-Human CCKBR/CCK2-R Polyclonal Antibody|抗人CCKBR/CCK2-R多克隆抗体(靶标：人胆囊收缩素B受体)
- 货号：RB9THB288014
- 价格：面议
- 点击：530
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | CCK-B receptor, CCK-BR, CCK2-R, CCKBR, CCKRB, Cholecystokinin-2 receptor, Gastrin/cholecystokinin type B receptor |
| 免疫原 | E. coli - derived recombinant Human CCKBR/CCK2-R (Arg243-Arg333). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P32239 |
| 背景信息 | Gastrin/cholecystokinin type B receptor (CCKBR/CCK2-R) is a ~48 kDa protein. Receptor for the peptide hormones gastrin and cholecystokinin (CCK). Expressed throughout the central nervous system, where it modulates processes such as anxiety, analgesia, arousal and neuroleptic activity. Couples to both GNAI1 and GNAQ signaling pathways, but not to GNAS. Upon gastrin activation, reduces glucose absorption in intestinal epithelial cells by downregulating SGLT1 and GLUT2 expression through suppression of the PI3K/Akt/eIF4B pathway. In the kidney, decreases SGLT2 expression under high-glucose conditions via ERK/NF-kappa-B signaling. 1. Zhang, X. et al. (2021) Nature chemical biology 17, 1230-1237. PMID: 34556863 |
| 备注 | For research use only |
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