| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | C-5 sterol desaturase, Delta(7)-sterol 5-desaturase, Delta(7)-sterol C5(6)-desaturase, EC:1.14.19.20, Lathosterol 5-desaturase, Lathosterol oxidase, SC5D, SC5DL, Sterol-C5-desaturase |
| 免疫原 | E. coli - derived recombinant Human SC5D (Ser207-Glu299). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | O75845 |
| 背景信息 | Lathosterol oxidase (SC5D) is a ~35 kDa protein. Catalyzes the penultimate step of the biosynthesis of cholesterol, the dehydrogenation of lathosterol into 7-dehydrocholesterol (7-DHC). Cholesterol is the major sterol component in mammalian membranes and a precursor for bile acid and steroid hormone synthesis. In addition to its essential role in cholesterol biosynthesis, it also indirectly regulates ferroptosis through the production of 7-DHC. By diverting the spread of damage caused by peroxyl radicals from the phospholipid components to its sterol nucleus, 7-DHC prevents this form of cell death. 1. Nishi, S. et al. (2000) Biochimica et biophysica acta 1490, 106-8. PMID: 10786622 2. Freitas, FP. et al. (2024) Nature 626, 401-410. PMID: 38297129 3. Li, Y. et al. (2024) Nature 626, 411-418. PMID: 38297130 |
| 备注 | For research use only |
| 产品名称 | 点击数 |
|---|---|
| 炔诺酮单抗 | 5897 |
| 磺胺氯吡嗪单抗 | 5893 |
| 呋喃苯烯酸钠单抗 | 5690 |
| 呋喃它酮代谢物(2-NPAMOZ)单抗 | 5687 |
| 呋喃西林代谢物(2-NPSEM)单抗 | 5512 |
| 磺胺喹恶啉单抗 | 5783 |
| 苯丙酸诺龙单抗 | 5688 |
| 司帕沙星单抗 | 5555 |
| 妥布霉素单抗 | 5690 |
| 甲氧氯普胺单抗 | 5536 |
| 莫能菌素单抗 | 5691 |
| 多粘菌素B(粘菌素)单抗 | 6024 |
| 磺胺类单抗 | 5931 |
| 托灭酸(托芬那酸)单抗 | 5564 |
| 卡洛芬单抗 | 5515 |
| 喹乙醇代谢物MQCA单抗 | 5689 |
| 氟尼辛单抗 | 5678 |
| 磺胺二甲嘧啶(SM2)单抗 | 5428 |
| 诺龙(19-去甲睾酮)单抗 | 5525 |
| 阿苯达唑-2-氨基砜单抗 | 5459 |