| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | C-5 sterol desaturase, Delta(7)-sterol 5-desaturase, Delta(7)-sterol C5(6)-desaturase, EC:1.14.19.20, Lathosterol 5-desaturase, Lathosterol oxidase, SC5D, SC5DL, Sterol-C5-desaturase |
| 免疫原 | E. coli - derived recombinant Human SC5D (Ser207-Glu299). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | O75845 |
| 背景信息 | Lathosterol oxidase (SC5D) is a ~35 kDa protein. Catalyzes the penultimate step of the biosynthesis of cholesterol, the dehydrogenation of lathosterol into 7-dehydrocholesterol (7-DHC). Cholesterol is the major sterol component in mammalian membranes and a precursor for bile acid and steroid hormone synthesis. In addition to its essential role in cholesterol biosynthesis, it also indirectly regulates ferroptosis through the production of 7-DHC. By diverting the spread of damage caused by peroxyl radicals from the phospholipid components to its sterol nucleus, 7-DHC prevents this form of cell death. 1. Nishi, S. et al. (2000) Biochimica et biophysica acta 1490, 106-8. PMID: 10786622 2. Freitas, FP. et al. (2024) Nature 626, 401-410. PMID: 38297129 3. Li, Y. et al. (2024) Nature 626, 411-418. PMID: 38297130 |
| 备注 | For research use only |
| 产品名称 | 点击数 |
|---|---|
| 过氧化物酶(HRP)标莱克多巴胺单克隆抗体 | 6303 |
| 过氧化物酶(HRP)标沙丁胺醇单克隆抗体 | 6294 |
| 呋喃唑酮代谢物(2-NPAOZ)单抗 | 6767 |
| 环丙沙星(CPFX)单抗 | 6203 |
| 氟喹诺酮类单抗 | 6308 |
| 恩诺沙星单抗 | 6172 |
| 环丙沙星|恩诺沙星|诺氟沙星三合一单抗 | 6204 |
| 睾酮单抗 | 6100 |
| 过氧化物酶(HRP)标睾酮单克隆抗体 | 6126 |
| 过氧化物酶(HRP)标雌三醇单克隆抗体 | 6345 |
| 过氧化物酶(HRP)标记甲基睾酮单克隆抗体 | 6608 |
| 黄曲霉毒素抗体(黄曲霉毒素B1,黄曲霉毒素总量单克隆抗体) | 6191 |
| 苏丹红1号单抗 | 6426 |
| 呋喃西林代谢物(2-NPSEM)单抗(40F11细胞株) | 6048 |
| 小鼠单克隆抗体Ig类/亚类鉴定ELISA试剂盒 | 6986 |
| 小鼠单克隆抗体Ig类/亚类/亚型鉴定ELISA试剂盒 | 7210 |
| 小鼠单克隆抗体Ig类/亚类/亚型鉴定酶标二抗即用套装 | 7108 |
| HRP标记小鼠单抗专用稀释液 | 7164 |
| 小鼠单抗腹水制备专用佐剂套装 | 7212 |
| 新冠病毒S蛋白中和抗体ELISA检测试剂盒 | 6911 |