Anti-Human SC5D Polyclonal Antibody|抗人SC5D多克隆抗体(靶标：人甾醇-C5-去饱和酶)
- 货号：RB9THD502014
- 价格：面议
- 点击：281
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | C-5 sterol desaturase, Delta(7)-sterol 5-desaturase, Delta(7)-sterol C5(6)-desaturase, EC:1.14.19.20, Lathosterol 5-desaturase, Lathosterol oxidase, SC5D, SC5DL, Sterol-C5-desaturase |
| 免疫原 | E. coli - derived recombinant Human SC5D (Ser207-Glu299). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | O75845 |
| 背景信息 | Lathosterol oxidase (SC5D) is a ~35 kDa protein. Catalyzes the penultimate step of the biosynthesis of cholesterol, the dehydrogenation of lathosterol into 7-dehydrocholesterol (7-DHC). Cholesterol is the major sterol component in mammalian membranes and a precursor for bile acid and steroid hormone synthesis. In addition to its essential role in cholesterol biosynthesis, it also indirectly regulates ferroptosis through the production of 7-DHC. By diverting the spread of damage caused by peroxyl radicals from the phospholipid components to its sterol nucleus, 7-DHC prevents this form of cell death. 1. Nishi, S. et al. (2000) Biochimica et biophysica acta 1490, 106-8. PMID: 10786622 2. Freitas, FP. et al. (2024) Nature 626, 401-410. PMID: 38297129 3. Li, Y. et al. (2024) Nature 626, 411-418. PMID: 38297130 |
| 备注 | For research use only |
相关产品:
| 产品名称 | 点击数 |
|---|---|
| CA-125单克隆抗体 | 6854 |
| PSA单克隆抗体 | 6922 |
| AFP单克隆抗体 | 6883 |
| CA-724单克隆抗体 | 6871 |
| CA-199单克隆抗体 | 6777 |
| HE4单克隆抗体 | 6611 |
| 孕酮单克隆抗体 | 7189 |
| 人胎球蛋白A(Fetuin A)单克隆抗体 | 7054 |
| 胎盘泌乳素单克隆抗体 | 6871 |
| 泌乳素单克隆抗体 | 6631 |
| SP-10单克隆抗体 | 6785 |
| AMH单克隆抗体 | 7165 |
| 胎儿纤维链接蛋白单克隆抗体 | 6950 |
| HCG单克隆抗体 | 6823 |
| 人骨碱性磷酸酶单克隆抗体 | 6695 |
| 小分子单克隆抗体 | 6902 |
| 抗环瓜氨酸肽抗体(Anti-CCP)诊断试剂原料 | 6823 |
| 耐碳青霉烯单克隆抗体 | 6989 |
| 补体C4c单克隆抗体 | 7218 |
| 补体C3c单克隆抗体 | 6801 |