| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | C-5 sterol desaturase, Delta(7)-sterol 5-desaturase, Delta(7)-sterol C5(6)-desaturase, EC:1.14.19.20, Lathosterol 5-desaturase, Lathosterol oxidase, SC5D, SC5DL, Sterol-C5-desaturase |
| 免疫原 | E. coli - derived recombinant Human SC5D (Ser207-Glu299). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | O75845 |
| 背景信息 | Lathosterol oxidase (SC5D) is a ~35 kDa protein. Catalyzes the penultimate step of the biosynthesis of cholesterol, the dehydrogenation of lathosterol into 7-dehydrocholesterol (7-DHC). Cholesterol is the major sterol component in mammalian membranes and a precursor for bile acid and steroid hormone synthesis. In addition to its essential role in cholesterol biosynthesis, it also indirectly regulates ferroptosis through the production of 7-DHC. By diverting the spread of damage caused by peroxyl radicals from the phospholipid components to its sterol nucleus, 7-DHC prevents this form of cell death. 1. Nishi, S. et al. (2000) Biochimica et biophysica acta 1490, 106-8. PMID: 10786622 2. Freitas, FP. et al. (2024) Nature 626, 401-410. PMID: 38297129 3. Li, Y. et al. (2024) Nature 626, 411-418. PMID: 38297130 |
| 备注 | For research use only |
| 产品名称 | 点击数 |
|---|---|
| 倍硫磷单抗 | 6299 |
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| 三氯噻嗪单抗 | 6466 |
| 吡唑醚菌酯单抗 | 6682 |
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| 赛拉嗪(甲苯噻嗪)单抗 | 6420 |
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| 多效唑单抗 | 6366 |
| 对硫磷单抗 | 6564 |
| 丙溴磷单抗 | 6602 |
| 戊唑醇单抗 | 6598 |
| 莠去津单抗 | 6475 |
| 灭蝇胺单抗 | 6170 |
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| 2.4-二氯苯氧乙酸单抗 | 6299 |
| 甲基对硫磷单抗 | 6383 |
| 左旋咪唑单抗 | 6311 |
| 三唑磷单抗 | 6391 |