Anti-Human MELK Polyclonal Antibody|抗人MELK多克隆抗体(靶标：人母体胚胎亮氨酸拉链激酶)
- 货号：RB9THC349014
- 价格：面议
- 点击：404
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Mouse |
| 靶标 | EC:2.7.10.2, EC:2.7.11.1, KIAA0175, MELK, Maternal embryonic leucine zipper kinase, Protein kinase Eg3, Protein kinase PK38, Tyrosine-protein kinase MELK, hMELK, hPK38, pEg3 kinase |
| 免疫原 | E. coli - derived recombinant Human MELK (Met1-Phe337). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q14680 |
| 背景信息 | Maternal embryonic leucine zipper kinase (MELK) is a ~74 kDa protein. Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. |
| 备注 | For research use only |
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