Anti-Human KLHL24 Polyclonal Antibody|抗人KLHL24多克隆抗体(靶标：人Kelch样蛋白24)
- 货号：RB9THD515014
- 价格：面议
- 点击：559
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human, Rat, Mouse |
| 靶标 | DRE1, KLHL24, KRIP6, Kainate receptor-interacting protein for GluR6, Kelch-like protein 24, Protein DRE1 |
| 免疫原 | E. coli - derived recombinant Human KLHL24 (Arg306-Leu600). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q6TFL4 |
| 背景信息 | Kelch-like protein 24 (KLHL24) is a ~68 kDa protein. Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation. Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties. Has a crucial role in cardiac development and function. 1. He, Y. et al. (2016) American journal of human genetics 99, 1395-1404. PMID: 27889062 2. Lin, Z. et al. (2016) Nature genetics 48, 1508-1516. PMID: 27798626 3. Hedberg-Oldfors, C. et al. (2019) Human molecular genetics 28, 1919-1929. PMID: 30715372 |
| 备注 | For research use only |
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