Anti-Human ATL2 Polyclonal Antibody|抗人ATL2多克隆抗体(靶标：人Atlastin GTP酶2)
- 货号：RB9THD526014
- 价格：面议
- 点击：305
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Human |
| 靶标 | ADP-ribosylation factor-like protein 6-interacting protein 2, ARL6IP2, ATL-2, ATL2, Atlastin-2, EC:3.6.5.- |
| 免疫原 | E. coli - derived recombinant Human ATL2 (Val61-Gly365). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q8NHH9 |
| 背景信息 | Atlastin-2 (ATL2) is a ~66 kDa protein. Atlastin-2 (ATL2) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect. Two atlastin-2 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). 1. Rismanchi, N. et al. (2008) Human molecular genetics 17, 1591-604. PMID: 18270207 2. Hu, J. et al. (2009) Cell 138, 549-61. PMID: 19665976 3. Morin-Leisk, J. et al. (2011) The Journal of cell biology 195, 605-15. PMID: 22065636 4. Wang, S. et al. (2016) eLife 5. PMID: 27619977 5. Crosby, D. et al. (2022) The Journal of cell biology 221. PMID: 34817557 |
| 备注 | For research use only |
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