Anti-Human ERLIN2 Polyclonal Antibody|抗人ERLIN2多克隆抗体(靶标：人ER脂筏相关蛋白2/SPFH2)
- 货号：RB9THF861014
- 价格：面议
- 点击：226
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Rat, Mouse, Human |
| 靶标 | C8orf2, ERLIN2, Endoplasmic reticulum lipid raft-associated protein 2, Erlin-2, SPFH domain-containing protein 2, SPFH2, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2 |
| 免疫原 | E. coli - derived recombinant Human ERLIN2 (Pro47-Asn339). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | O94905 |
| 背景信息 | Erlin-2 (ERLIN2) is a ~37 kDa protein. Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex. 1. Pearce, MM. et al. (2007) The Journal of biological chemistry 282, 20104-15. PMID: 17502376 2. Pearce, MM. et al. (2009) The Journal of biological chemistry 284, 10433-45. PMID: 19240031 3. Jo, Y. et al. (2011) The Journal of biological chemistry 286, 15022-31. PMID: 21343306 4. Huber, MD. et al. (2013) The Journal of cell biology 203, 427-36. PMID: 24217618 |
| 备注 | For research use only |
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