Anti-Human PDE12 Polyclonal Antibody|抗人PDE12多克隆抗体(靶标：人磷酸二酯酶12)
- 货号：RB9THD532014
- 价格：面议
- 点击：401
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Human, Rat |
| 靶标 | 2',5'-phosphodiesterase 12, 2'-PDE, 2-PDE, EC:3.1.13.4, EC:3.1.4.-, Mitochondrial deadenylase, PDE12 |
| 免疫原 | E. coli - derived recombinant Human PDE12 (Thr276-Lys609). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q6L8Q7 |
| 背景信息 | 2',5'-phosphodiesterase 12 (PDE12) is a ~67 kDa protein. Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells. 1. Wood, ER. et al. (2015) The Journal of biological chemistry 290, 19681-96. PMID: 26055709 2. Rorbach, J. et al. (2011) Nucleic acids research 39, 7750-63. PMID: 21666256 3. Estrella, MA. et al. (2018) Scientific reports 8, 16294. PMID: 30389976 |
| 备注 | For research use only |
相关产品:
| 产品名称 | 点击数 |
|---|---|
| CA-125单克隆抗体 | 6786 |
| PSA单克隆抗体 | 6838 |
| AFP单克隆抗体 | 6800 |
| CA-724单克隆抗体 | 6797 |
| CA-199单克隆抗体 | 6695 |
| HE4单克隆抗体 | 6514 |
| 孕酮单克隆抗体 | 7067 |
| 人胎球蛋白A(Fetuin A)单克隆抗体 | 6996 |
| 胎盘泌乳素单克隆抗体 | 6801 |
| 泌乳素单克隆抗体 | 6579 |
| SP-10单克隆抗体 | 6705 |
| AMH单克隆抗体 | 7087 |
| 胎儿纤维链接蛋白单克隆抗体 | 6839 |
| HCG单克隆抗体 | 6728 |
| 人骨碱性磷酸酶单克隆抗体 | 6635 |
| 小分子单克隆抗体 | 6788 |
| 抗环瓜氨酸肽抗体(Anti-CCP)诊断试剂原料 | 6730 |
| 耐碳青霉烯单克隆抗体 | 6910 |
| 补体C4c单克隆抗体 | 7159 |
| 补体C3c单克隆抗体 | 6737 |