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Anti-Human FMO5 Polyclonal Antibody|抗人FMO5多克隆抗体(靶标:人含黄素单加氧酶5)

  • 货号:RB9THD536014
  • 价格:面议
  • 点击:163

产品介绍

产品参数

形态Liquid
宿主种属Rabbit
克隆性Polyclonal
抗体亚型IgG
纯化方式Purified by antigen affinity column.
内毒素水平Please contact with the lab for this information.
应用ELISA, IHC, WB
种属反应性Human
靶标Baeyer-Villiger monooxygenase 1, Dimethylaniline monooxygenase [N-oxide-forming] 5, Dimethylaniline oxidase 5, EC:1.14.13.-, EC:1.14.13.8, EC:1.6.3.1, FMO 5, FMO5, Flavin-containing monooxygenase 5, N
免疫原E. coli - derived recombinant Human FMO5 (Met1-Ser512).
储存缓冲液0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
产品使用说明ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
登录号P49326
背景信息

Flavin-containing monooxygenase 5 (FMO5) is a ~60 kDa protein. Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline.

1. Lai, WG. et al. (2011) Drug metabolism and disposition: the biological fate of chemicals 39, 61-70. PMID: 20947616
2. Fiorentini, F. et al. (2016) ACS chemical biology 11, 1039-48. PMID: 26771671
3. Fiorentini, F. et al. (2017) ACS chemical biology 12, 2379-2387. PMID: 28783300
4. Overby, LH. et al. (1995) Archives of biochemistry and biophysics 317, 275-84. PMID: 7872795
备注For research use only
【仅供科学研究使用】

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