| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | Baeyer-Villiger monooxygenase 1, Dimethylaniline monooxygenase [N-oxide-forming] 5, Dimethylaniline oxidase 5, EC:1.14.13.-, EC:1.14.13.8, EC:1.6.3.1, FMO 5, FMO5, Flavin-containing monooxygenase 5, N |
| 免疫原 | E. coli - derived recombinant Human FMO5 (Met1-Ser512). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | P49326 |
| 背景信息 | Flavin-containing monooxygenase 5 (FMO5) is a ~60 kDa protein. Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. 1. Lai, WG. et al. (2011) Drug metabolism and disposition: the biological fate of chemicals 39, 61-70. PMID: 20947616 2. Fiorentini, F. et al. (2016) ACS chemical biology 11, 1039-48. PMID: 26771671 3. Fiorentini, F. et al. (2017) ACS chemical biology 12, 2379-2387. PMID: 28783300 4. Overby, LH. et al. (1995) Archives of biochemistry and biophysics 317, 275-84. PMID: 7872795 |
| 备注 | For research use only |
| 产品名称 | 点击数 |
|---|---|
| 阿苯达唑砜单抗 | 5494 |
| 金刚烷胺单抗 | 5523 |
| 卡那霉素单抗 | 5696 |
| 黄曲霉毒素M1(AFM1)单抗 | 5671 |
| 群勃龙(孕三烯酮)(去甲雄三烯醇酮)单抗 | 5821 |
| 帕托珠利(妥曲珠利砜)单抗 | 5583 |
| 泰乐菌素单抗 | 5617 |
| 替米考星单抗 | 5711 |
| 新霉素单抗 | 5719 |
| 安普霉素单抗 | 5652 |
| 三聚氰胺(MEL)单抗 | 5573 |
| 双氟沙星单抗 | 5489 |
| 西地那非单抗 | 5635 |
| 阿苯达唑单抗 | 5433 |
| 醋酸甲羟孕酮(醋酸甲孕酮)单抗 | 5592 |
| 氟苯尼考单抗 | 5620 |
| 诺龙单抗 | 5709 |
| 达氟沙星单抗 | 5817 |
| 培氟沙星单抗 | 5685 |
| 庆大霉素单抗 | 5830 |