Anti-Human BIRC6 Polyclonal Antibody|抗人BIRC6多克隆抗体(靶标：人含杆状病毒IAP重复序列蛋白6)
- 货号：RB9THV669014
- 价格：面议
- 点击：551
产品介绍
产品参数
| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Mouse, Human |
| 靶标 | APOLLON, BIR repeat-containing ubiquitin-conjugating enzyme, BIRC6, BRUCE, Baculoviral IAP repeat-containing protein 6, Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6, EC:2.3.2 |
| 免疫原 | E. coli - derived recombinant Human BIRC6 (Arg4576-Leu4857). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q9NR09 |
| 背景信息 | Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 is a ~530 kDa protein. Anti-apoptotic protein known as inhibitor of apoptosis (IAP) which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Unlike most IAPs, does not contain a RING domain and it is not a RING-type E3 ligase. Instead acts as a dual E2/E3 enzyme that combines ubiquitin conjugating (E2) and ubiquitin ligase (E3) activities in a single polypeptide. Ubiquitination is mediated by a non-canonical E1 ubiquitin activating enzyme UBA6. Ubiquitinates CASP3, CASP7 and CASP9 and inhibits their caspase activity; also ubiquitinates their procaspases but to a weaker extent. 1. Qiu, XB. et al. (2004) The EMBO journal 23, 800-10. PMID: 14765125 2. Bartke, T. et al. (2004) Molecular cell 14, 801-11. PMID: 15200957 3. Pohl, C. et al. (2008) Cell 132, 832-45. PMID: 18329369 4. Hunkeler, M. et al. (2023) Science (New York, N.Y.) 379, 1105-1111. PMID: 36758104 5. Ehrmann, JF. et al. (2023) Science (New York, N.Y.) 379, 1117-1123. PMID: 36758105 6. Dietz, L. et al. (2023) Science (New York, N.Y.) 379, 1112-1117. PMID: 36758106 |
| 备注 | For research use only |
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