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Anti-Human MTARC1 Polyclonal Antibody|抗人MTARC1多克隆抗体(靶标:人线粒体脒基还原酶1)

  • 货号:RB9THV197014
  • 价格:面议
  • 点击:514
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产品介绍

产品参数

形态Liquid
宿主种属Rabbit
克隆性Polyclonal
抗体亚型IgG
纯化方式Purified by antigen affinity column.
内毒素水平Please contact with the lab for this information.
应用ELISA, IHC, WB
种属反应性Human
靶标EC:1.7.-.-, MARC1, MOSC domain-containing protein 1, MOSC1, MTARC1, Mitochondrial amidoxime-reducing component 1, Moco sulfurase C-terminal domain-containing protein 1, Molybdenum cofactor sulfurase C
免疫原E. coli - derived recombinant Human MTARC1 (Arg41-Leu335).
储存缓冲液0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
产品使用说明ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000
登录号Q5VT66
背景信息

Mitochondrial amidoxime-reducing component 1 (MTARC1) is a ~37 kDa protein. Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction.

1. Gruenewald, S. et al. (2008) Journal of medicinal chemistry 51, 8173-7. PMID: 19053771
2. Kotthaus, J. et al. (2011) The Biochemical journal 433, 383-91. PMID: 21029045
3. Kubitza, C. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 11958-11963. PMID: 30397129
备注For research use only
【仅供科学研究使用】

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