| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | EC:1.7.-.-, MARC1, MOSC domain-containing protein 1, MOSC1, MTARC1, Mitochondrial amidoxime-reducing component 1, Moco sulfurase C-terminal domain-containing protein 1, Molybdenum cofactor sulfurase C |
| 免疫原 | E. coli - derived recombinant Human MTARC1 (Arg41-Leu335). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q5VT66 |
| 背景信息 | Mitochondrial amidoxime-reducing component 1 (MTARC1) is a ~37 kDa protein. Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction. 1. Gruenewald, S. et al. (2008) Journal of medicinal chemistry 51, 8173-7. PMID: 19053771 2. Kotthaus, J. et al. (2011) The Biochemical journal 433, 383-91. PMID: 21029045 3. Kubitza, C. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 11958-11963. PMID: 30397129 |
| 备注 | For research use only |
| 产品名称 | 点击数 |
|---|---|
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| 阿米巴单克隆抗体 | 7965 |
| 胃蛋白酶单克隆抗体 | 7430 |
| 胃蛋白酶原II单克隆抗体 | 7676 |
| 胃蛋白酶原I单克隆抗体 | 7378 |
| 艰难梭菌毒素A单克隆抗体 | 7531 |
| 艰难梭菌毒素B单克隆抗体 | 7841 |
| 艰难梭菌GDH单克隆抗体 | 7824 |
| 诺如病毒单克隆抗体 | 7313 |
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| 鼠疫耶尔森菌F1单克隆抗体 | 6897 |
| 幽门螺杆菌单克隆抗体 | 7434 |
| 钙卫蛋白单克隆抗体 | 7199 |
| 乳铁蛋白单克隆抗体 | 7566 |
| 转铁蛋白单克隆抗体 | 7559 |
| 血红蛋白单克隆抗体 | 7275 |
| 腺病毒单克隆抗体 | 7495 |
| 轮状病毒单克隆抗体 | 7904 |