| 形态 | Liquid |
|---|---|
| 宿主种属 | Rabbit |
| 克隆性 | Polyclonal |
| 抗体亚型 | IgG |
| 纯化方式 | Purified by antigen affinity column. |
| 内毒素水平 | Please contact with the lab for this information. |
| 应用 | ELISA, IHC, WB |
| 种属反应性 | Human |
| 靶标 | EC:1.7.-.-, MARC1, MOSC domain-containing protein 1, MOSC1, MTARC1, Mitochondrial amidoxime-reducing component 1, Moco sulfurase C-terminal domain-containing protein 1, Molybdenum cofactor sulfurase C |
| 免疫原 | E. coli - derived recombinant Human MTARC1 (Arg41-Leu335). |
| 储存缓冲液 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| 产品使用说明 | ELISA:1:5000-1:20000;IHC:1:50-1:500;WB:1:500-1:2000 |
| 登录号 | Q5VT66 |
| 背景信息 | Mitochondrial amidoxime-reducing component 1 (MTARC1) is a ~37 kDa protein. Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction. 1. Gruenewald, S. et al. (2008) Journal of medicinal chemistry 51, 8173-7. PMID: 19053771 2. Kotthaus, J. et al. (2011) The Biochemical journal 433, 383-91. PMID: 21029045 3. Kubitza, C. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 11958-11963. PMID: 30397129 |
| 备注 | For research use only |
| 产品名称 | 点击数 |
|---|---|
| 倍硫磷单抗 | 6303 |
| 多菌灵/阿苯达唑二合一单抗 | 6377 |
| 三氯噻嗪单抗 | 6468 |
| 吡唑醚菌酯单抗 | 6688 |
| 烯酰吗啉单抗 | 6507 |
| 抑霉唑单抗 | 6232 |
| 恶醚唑(苯醚甲环唑)单抗 | 6405 |
| 赛拉嗪(甲苯噻嗪)单抗 | 6423 |
| 辛硫磷单抗 | 6496 |
| 多效唑单抗 | 6368 |
| 对硫磷单抗 | 6566 |
| 丙溴磷单抗 | 6612 |
| 戊唑醇单抗 | 6604 |
| 莠去津单抗 | 6482 |
| 灭蝇胺单抗 | 6176 |
| 尼卡巴嗪代谢物(DNC)单抗 | 6463 |
| 2.4-二氯苯氧乙酸单抗 | 6307 |
| 甲基对硫磷单抗 | 6388 |
| 左旋咪唑单抗 | 6318 |
| 三唑磷单抗 | 6397 |